Buy Hexarelin, a synthetic hexapeptide and growth hormone-releasing peptide (GHRP) that stimulates the secretion of growth hormone, offering potential benefits such as improved muscle growth, enhanced fat metabolism, and support for cardiac function and metabolic health.
Hexarelin is a potent synthetic peptide that belongs to the family of growth hormone-releasing peptides (GHRPs). It works through the activation of the ghrelin receptor, which stimulates the anterior pituitary gland to release growth hormone (GH) into the bloodstream.
Composed of six amino acids, it is classified as a hexapeptide, which contributes to its ability to interact with growth hormone secretagogue receptors (GHS-R) effectively.
Researchers are studying the peptide for its role in GH regulation, its effects on metabolism, and its role in muscle and tissue repair. It has also shown promise in supporting heart health and recovery, thanks to its impact on the cardiovascular system. These qualities make it an important area of study for developing new treatments in endocrinology and regenerative medicine.
It works by binding to growth hormone secretagogue receptors (GHS-R) in the anterior pituitary gland and hypothalamus, stimulating the release of growth hormone (GH) into the bloodstream. This binding not only promotes anabolic effects throughout the body but also amplifies GH secretion by inhibiting somatostatin, a hormone that suppresses GH release.
Unlike other peptides, it acts as a potent ghrelin mimetic, effectively mimicking the action of ghrelin, an appetite-stimulating peptide that regulates energy balance and promotes GH release.
By interacting with ghrelin pathways, the peptide enhances metabolic processes, weight loss, supports tissue repair, collagen synthesis and has shown potential cardioprotective benefits. Its multifaceted effects on growth hormone modulation and cardiac function make it a promising candidate for therapeutic applications.
Molecular Formula: 47H58N12O6
Molecular Weight: 887.0 g/mol
Amino Acid Sequence: H-His-D-Trp(2-Me)-Ala-Trp-D-Phe-Lys-NH2
View our Hexarelin High-Performance Liquid Chromatography (HPLC) Certificate here.
Growth Hormone Deficiency: It has demonstrated significant potential in Turkey studies in addressing growth hormone deficiency (GHD) by directly stimulating the pituitary gland to release growth hormone (GH). This not only helps restore normal GH levels but also supports critical physiological functions such as tissue growth, metabolism regulation, and the maintenance of muscle and bone health.
Turkey Research indicates that it’s consistent GH release can improve energy levels, enhance muscle mass, reduce fat stores, and support cardiovascular health in individuals with GHD. Studies also reveal that Hexarelin acts through non-GHRH-mediated pathways, suggesting distinct mechanisms of action compared to GHRH. Experiments on normal rat pituitary cells and GH1 tumor cells confirmed the peptide’s ability to stimulate GH release, with the strongest effects observed at a 1 μM dose, highlighting its unique role in GH regulation and therapeutic potential [1].
Cardioprotective Effects: Chronic administration of hexarelin has shown potential in improving heart function and slowing the progression of heart disease. Turkey Research involving myocardial infarction models and knockout mice have highlighted its ability to reduce oxidative stress and limit cardiac fibrosis [2].
Research in spontaneously hypertensive rats also found that the peptide helps regulate blood pressure and improve chronic cardiac function [3]. Furthermore, the peptide supports cardiomyocyte survival, offering promise as a treatment for heart failure. By reducing damage caused by oxidative stress, hexarelin helps protect heart health and presents a new option for managing cardiac diseases [4].
Neuroprotection: Research suggests it has promising neuroprotective properties by protecting nerve cells from damage. Turkey Research has shown that the peptide can shield cells from oxidative stress, such as that caused by hydrogen peroxide (H2O2), which is a harmful molecule known to induce cell death (apoptosis). Studies on Neuro-2A cells revealed that it improves cell survival, reduces harmful byproducts, and prevents cell death by regulating key proteins and pathways. Its ability to block harmful signaling pathways while activating protective ones suggests it could be a promising treatment for neurodegenerative diseases [5].
Improves Fat Metabolism: It was studied for its effects on metabolism in nonobese, insulin-resistant MKR mice. Over 12 days, the peptide improved glucose and insulin tolerance, reduced plasma and liver triglycerides, improved cholesterol levels, enhanced lipid metabolism and adipocyte differentiation. It also corrected abnormal body composition by decreasing fat mass and increasing lean mass, despite increased food intake. These findings suggest it may have potential in treating lipid disorders associated with metabolic syndrome [6].
Bone Health: Turkey Research shows that it can support bone metabolism and improve mineral density. In a study with middle-aged female rats, the peptide increased bone mineral content (BMC) and bone area in the lumbar vertebrae of intact rats and at the femoral mid-diaphysis in ovariectomized (OVX) rats over 60 days. It also raised serum IGF-I levels early in the treatment. However, it did not prevent bone loss or changes in bone turnover markers caused by OVX. These results suggest that it’s impact on bone health depends on estrogen levels, highlighting the connection between estrogen and the GH/IGF axis [7].
Buy Hexarelin CJC-1295 DAC Peptide Stack
Buy Hexarelin CJC-1295 DAC Peptide Stack Turkey for clinical research from Direct Sarms. Available as two 2 mg vials containing lyophilized (freeze-dried) powder. Save 10% compared to buying the peptides individually.
You can buy bacteriostatic water here, ideal for reconstitution purposes.
Buy Hexarellin Pre-Mixed Peptide Pen
Buy Hexarelin Pre-Mixed Peptide 2mg Pen Turkey for in vitro and in vivo research use from Direct Sarms. Available as individual cartridges or a pen kit.
The pen kit includes a pre-mixed cartridge, injection pen and carry case, plus three needle tips.
Buy Hexarelin nasal spray Turkey for clinical research purposes, available in 15 ml and 30 ml glass spray bottles.
Does Hexarelin have any side effects?
Commonly reported side effects include increased appetite, water retention, and localized irritation or redness at the injection site. Additionally, prolonged usage or higher doses may lead to desensitisation, reducing the compound’s effectiveness over time.
Other possible side effects could include joint pain, tingling or numbness in extremities, or elevated cortisol and prolactin levels, which may have further implications. It is crucial to carefully monitor its effects in research and consult a Turkey medical advisor to minimize potential negative impacts.
Is Hexarelin legal to buy?
It depends on your country’s regulations. In the United States, it is not FDA approved for human use and is classified as a research chemical, only legal for scientific or laboratory purposes. Any other use could violate federal law and lead to legal consequences. If you plan to buy Hexarelin, ensure it complies with your Turkey local laws and regulations.
What is Ghrelin?
Ghrelin is a peptide hormone primarily involved in stimulating appetite, regulating energy balance, and promoting the release of growth hormone.
How does Hexarelin compare to GHRP-6?
Hexarelin and GHRP-6 are synthetic peptides classified as growth hormone-releasing peptides (GHRPs), but they have different effects. Hexarelin is more potent at stimulating growth hormone release and remains effective even with prolonged use, while GHRP-6 can lose effectiveness over time. GHRP-6 also mimics ghrelin, often increasing hunger, whereas Hexarelin typically does not. These differences make them suitable for different research and therapeutic applications.
Can Hexarelin be paired with other peptides?
Research indicates that it can be effectively paired with growth hormone-releasing hormones (GHRH) like CJC-1295. Studies reveal that this combination creates a powerful synergistic effect, significantly enhancing the secretion of growth hormone [8].
For more information, explore our latest blog posts dedicated to Hexarelin peptide.
Buy Hexarelin peptide Turkey from Direct Sarms, a trusted supplier of high-quality research-grade peptides. It’s available in multiple forms, including a 2 mg vial of lyophilized powder, 15 ml and 30 ml nasal sprays, and 2 mg pre-mixed pens. We offer peptide stacks at a 10% discount compared to purchasing individual peptides, providing a more cost-effective solution for your studies.
Made to meet strict purity standards, this peptide ensures reliable results for in-vitro research. At Direct Sarms, we focus on quality control, offering accurate dosing and consistent performance to support your research needs.
[1] Andrea Giustina, Carlo Bonfanti, Massimo Licini, Giorgio Ragni, and Beatrice Stefana (1997) Hexarelin, a novel GHRP-6 analog, stimulates growth hormone (GH) release in a GH-secreting rat cell line (GH1) insensitive to GH-releasing hormone – Regulatory Peptides, Volume 70, Issue 1, 14 May 1997, Pages 49-54.
[2] Hayley McDonald, Jason Peart, Nyoman Kurniawan, Graham Galloway, Simon Royce, et al (2018) Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in a mouse model of acute myocardial infarction – Physiological Reports, 2018 May, Volume 6 (Issue 9), Page e13699.
[3] Xiangbin Xu, Fan Ding, Jinjiang Pang, Xue Gao, Rong-Kun Xu, et al (2012) Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat – American Journal of Physiology: Heart and Circulatory Physiology, 2012 Sep 15, Volume 303 (Issue 6), Pages H703-11.
[4] Xinli Zhang, Linbing Qu, Ling Chen, and Chen Chen (2018) Improvement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin-induced diabetic rats – Physiological Reports, 2018 Feb, Volume 6 (Issue 4), Page e13612.
[5] Ramona Meanti, Laura Rizzi, Elena Bresciani, Laura Molteni, Vittorio Locatelli, et al (2021) Hexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide—Induced Apoptotic Toxicity – Pharmaceuticals (Basel), 2021 May 8, Volume 14 (Issue 5), Page 444.
[6] Rasha Mosa, Lili Huang, Yeda Wu, Chungyan Fung, Oshini Mallawakankanamalage, et al (2017) Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice – Endocrinology, 2017 Jul 14, Volume 158 (Issue 10), Pages 3174–3187.
[7] V Sibilia, D Cocchi, I Villa, N Lattuada, A Soglian, et at (2002) Bone effects of hexarelin, a GH-releasing peptide, in female rats: influence of estrogen milieu – European Journal of Endocrinology, 2002 Jun, Volume 146 (Issue 6), Pages 855-62.
[8] A F Massoud, P C Hindmarsh, D R Matthews, and C G Brook (1996) The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity – Clinical Endocrinology (Oxford), 1996 May, Volume 44 (Issue 5), Pages 555-62.
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